SpaSEG Revolutionizes Spatial Transcriptomics: Simplifying 3D Tissue Mapping & Large-Scale Data Analysis

3 days ago 高效码农

From Data Chaos to Tissue Atlases: How SpaSEG Makes Spatial Transcriptomics Simple 1. Why Spatial Transcriptomics Matters (and Where It Hurts) Imagine cutting a thin slice of brain or tumor tissue and asking, “Which genes are where?” Spatial transcriptomics (SRT) does exactly that. Instead of grinding tissue into single-cell soup, it keeps every cell in its original neighborhood and records gene activity in situ. The payoff: you can see immune cells swarming around a tumor margin, or layer-specific neurons sitting exactly where they should. The pain: a single experiment can produce half a million data points—each carrying thousands of gene …

Interpretable Biological AI: BioReason Bridges DNA Models and Language AI for Transparent Genomics

2 months ago 高效码农

BioReason: When DNA Models Meet Language AI, Biological Reasoning Becomes Interpretable “ This multimodal AI framework achieves seamless integration of DNA sequences and natural language, enabling machines to “reason” about disease mechanisms like biologists. The Bottleneck in Biomedical AI: Black-Box Models and Missing Reasoning Capabilities Genomics researchers face two persistent challenges: 1. The Black Box Dilemma of DNA Foundation Models Models like Evo2 and Nucleotide Transformer demonstrate impressive performance in splice site identification and variant effect prediction through pretraining on massive genomic datasets. Yet they operate as opaque systems—while generating predictions, they cannot explain why a genetic variant causes disease …